RDD043

氯化乙酰胆碱

≥99% (TLC), free-flowing, Redi-Dri^™

• 同義詞: ACh
• 線性公式: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• CAS號碼: 60-31-1
• 分子量：: 181.66
• Beilstein: 3571875
• MDL號碼: MFCD00011698
• 分類程式碼代碼: 51151535
• NACRES: NA.25

屬性

• 產品線: Redi-Dri^™
• 品質等級: 100
• 化驗: ≥99% (TLC)
• 形狀: powder
• 品質: free-flowing
• 包裝: pkg of 100 g
• 顏色: white to faint yellow cast
• mp: 146-150 °C (lit.)
• 溶解度: H₂O: 100 mg/mL
• 密度: 1.27 g/cm³
• 儲存溫度: room temp
• SMILES 字串: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI 密鑰: JUGOREOARAHOCO-UHFFFAOYSA-M

描述

一般說明

Acetylcholine Chloride, the chloride salt of acetylcholine, is a synthetic amino alcohol with cholinergic properties, making it a vital component in biochemical and neurotransmission studies. It replicates the effects of the endogenous acetylcholine compound, which plays a significant role in the immune system, inflammation, and allergy research. Acetylcholine chloride acts as a cholinergic neurotransmitter, binding to nicotinic and muscarinic acetylcholine receptors, facilitating the opening of calcium channels.Furthermore, Acetylcholine chloride (ACh chloride) functions as a potent cholinergic agonist, influencing the activity of dopaminergic (DAergic) neurons by stimulating nicotinic acetylcholine receptors (nAChRs). This feature is particularly relevant in studies related to the immune system and inflammation. Additionally, it demonstrates the capacity to inhibit the aggregation of p53 mutant peptide in vitro, which contributes to the exploration of biochemical and allergy research.

應用

Acetylcholine chloride has been used:

• as an agent to trigger sudomotor axon reflex response during autonomic test
• to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats
• as a substrate for acetylcholinesterase
• to stimulate after discharge in Aplysia bag cell neurons

生化／生理作用

氯化乙酰胆碱，20mg/kg体重注射，减少小鼠实验性诱发脓毒病的死亡和血浆促炎细胞因子。类胆碱能抗-炎症机制可能通过乙酰胆碱和 α7n单核细胞，巨噬细胞和中性粒细胞上的胆红素受体互作接待，降低了促炎细胞活素，比如 TNF-α,IL-1β,和IL-6。

胆碱能突触中的内源性神经递质，通过增强肌膜动作电位来触发肌肉收缩反应。

特點和優勢

• Redi-Dri^™ format for Improved Efficiency and Time Savings
• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

注意

非常吸湿

其他說明

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法律資訊

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable