PHL89708

高三尖杉酯碱

phyproof^® Reference Substance

• 同義詞: Ceflatonin, Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate, Myelostat, NSC 141633, Omacetaxine mepesuccinate
• 經驗公式（希爾表示法）: C₂₉H₃₉NO₉
• CAS號碼: 26833-87-4
• 分子量：: 545.62
• MDL號碼: MFCD03410264
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: primary reference standard
• 產品線: phyproof^® Reference Substance
• 化驗: ≥95.0% (HPLC)
• 製造商／商標名: PhytoLab
• 應用: food and beverages
• 形式: neat
• 儲存溫度: −20°C
• SMILES 字串: COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@H]1C2c3cc4OCOc4cc3CCN5CCC[C@]25C=C1OC
• InChI: 1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
• InChI 密鑰: HYFHYPWGAURHIV-JFIAXGOJSA-N

描述

一般說明

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

生化／生理作用

Homoharringtonine (Omacetaxine mepesuccinate) is a translation elongation inhibitor, a cytotoxic alkaloid originally isolated from the evergreen tree, Cephalotaxus hainanensis. Homoharringtonine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. Homoharringtonine blocks progression of leukemic cells from G1 phase into S phase and from G2 phase into M phase. Homoharringtonine (Omacetaxine mepesuccinate) was approved in October 2012 (Synribo) for the treatment of adult patients with Chronic Myelogenous Leukemia (CML) with resistance and/or intolerance to two or more tyrosine kinase inhibitors.

Homoharringtonine is a translation elongation inhibitor.

法律資訊

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300 + H310 + H330
• 防範說明: P260 - P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 - P403 + P233
• 危險分類: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable