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P9672

Supelco

普罗布考

analytical standard

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About This Item

經驗公式（希爾表示法）:
C31H48O2S2
CAS號碼:
23288-49-5
分子量：:
516.84
EC號碼:
245-560-9
MDL號碼:
MFCD00079281
分類程式碼代碼:
41116107
PubChem物質ID:
329820354
NACRES:
NA.24

等級

analytical standard

品質等級

200

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

forensics and toxicology
pharmaceutical (small molecule)

形式

neat

SMILES 字串

CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C

InChI

1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3

InChI 密鑰

FYPMFJGVHOHGLL-UHFFFAOYSA-N

基因資訊

human ... ABCA1(19) , IL1B(3553) , IL6(3569) , TNF(7124)

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相關類別

一般說明

Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties. It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).

應用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化／生理作用

提高 HDL 相关胆固醇酯的选择性摄取

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number
SLCM2132
SLBS3412V
SLBR2496V
MKBQ8447V
SLBD2845V

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Zhiwen Zhang et al.
International journal of pharmaceutics, 444(1-2), 162-168 (2013-01-24)
The therapeutic efficacy of lipophilic drugs is commonly restricted by the low systemic exposure after oral administration. In this work, a new delivery system combining the advantages of porous starch and self-assembled nanocarrier was designed to improve the oral absorption
Atherosclerosis: Treatment and Prevention (2012)
Miwako Inagaki et al.
Journal of atherosclerosis and thrombosis, 19(7), 643-656 (2012-07-13)
High density lipoprotein (HDL) has multi-antiatherogenic effects such as antioxidation and anti-inflammation, in addition to being a key mediator of reverse cholesterol transport. Probucol, known as a lipid lowering drug, is also a potent antioxidant, but it decreases serum HDL
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics (2013)
Jonathan Watt et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 81(4), 698-708 (2012-05-15)
The aim of this study was to assess the efficacy of stent-based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Current drugs and polymers used to coat coronary stents remain suboptimal in terms of
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文章

Cholesterol Transport

Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are called lipoproteins.

Cholesterol Transport

Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are called lipoproteins.

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