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Merck
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重要文件

M0600000

美雌醇

European Pharmacopoeia (EP) Reference Standard

同義詞:

17α-乙炔基-1,3,5(10)-雌三烯-3,17β-二醇 3-甲醚, 17α-乙炔雌二醇 3-甲醚, 3-甲氧基-17α-乙炔雌二醇

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About This Item

經驗公式(希爾表示法):
C21H26O2
CAS號碼:
分子量::
310.43
Beilstein:
2625905
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

mestranol

製造商/商標名

EDQM

mp

153-155 °C (lit.)

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

COc1ccc2C3CC[C@@]4(C)C(CC[C@@]4(O)C#C)C3CCc2c1

InChI

1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3/t17-,18-,19+,20+,21+/m1/s1

InChI 密鑰

IMSSROKUHAOUJS-MJCUULBUSA-N

基因資訊

human ... ESR1(2099)

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

相關產品

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險聲明

危險分類

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Mestranol.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 21, 257-278 (1979-12-01)
J W Goldzieher et al.
American journal of obstetrics and gynecology, 163(6 Pt 2), 2114-2119 (1990-12-01)
Pharmacokinetally, a 50 micrograms oral dose of mestranol (which itself is inactive) is bioequivalent to a 35 micrograms dose of ethinyl estradiol. Physiologically, mestranol ranges from 50% to 100% of the activity of ethinyl estradiol, depending on the endpoint chosen.
[Comparative study of the effect of ethinyl estradiol and mestranol. Clinical data from the literature].
R Pellegrini et al.
Quaderni di clinica ostetrica e ginecologica, 24(9), 597-617 (1969-09-01)
Si Wang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 78-89 (2014-06-15)
In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenicity, i.e., other

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