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重要文件

34007

Supelco

羟基甲硝唑

VETRANAL®, analytical standard

同義詞:

1-(2-羟乙基)-2-羟甲基-5-硝基咪唑, MNZOH, 羟基甲硝唑

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About This Item

經驗公式(希爾表示法):
C6H9N3O4
CAS號碼:
分子量::
187.15
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

analytical standard

品質等級

產品線

VETRANAL®

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

forensics and toxicology
pharmaceutical (small molecule)

形式

neat

SMILES 字串

OCCn1c(CO)ncc1[N+]([O-])=O

InChI

1S/C6H9N3O4/c10-2-1-8-5(4-11)7-3-6(8)9(12)13/h3,10-11H,1-2,4H2

InChI 密鑰

AEHPOYAOLCAMIU-UHFFFAOYSA-N

一般說明

羟基甲硝唑是一种基因毒性、致癌和致突变的硝基咪唑类药物,可作为广谱兽药治疗和预防农场动物的细菌和原虫感染疾病。

應用

有关合适仪器技术的更多信息,请参考产品′s分析证书。如需进一步支持,请联系技术服务。
羟基甲硝唑可作为标准品,通过超高效液相色谱 (UPLC) -四极杆/线性离子阱质谱法 (UPLC-Qtrap-MS/MS)和超高效液相色谱 -飞行时间质谱 (TOF) 法测定水样和肉类基质中的羟基甲硝唑抗生素。

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法律資訊

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

C S Easmon et al.
The British journal of venereal diseases, 58(4), 246-249 (1982-08-01)
The hydroxy metabolite of metronidazole was found to be more active against 21 strains of Gardnerella vaginalis than the parent compound and less affected by culture in carbon dioxide. After 400 mg oral metronidazole (Flagyl) plasma concentrations of the two
Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-particulate high-performance liquid chromatography coupled to time of flight mass spectrometry.
Kaufmann A, et al.
Journal of Chromatography A, 1194(1), 66-79 (2008)
M N Muscará et al.
British journal of clinical pharmacology, 40(5), 477-480 (1995-11-01)
Metronidazole pharmacokinetics were studied in patients with different degrees of liver cirrhosis, classified according to the Child-Pugh algorithm (A, B or C, as liver disease severity increases) and in schistosomic patients. Metronidazole (500 mg) was administered i.v. as a slow
Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry.
Gros M, et al.
Journal of Chromatography A, 1248(6), 104-121 (2012)
S L Pendland et al.
Antimicrobial agents and chemotherapy, 38(9), 2106-2110 (1994-09-01)
Metronidazole is metabolized to two major oxidative products: an acid metabolite and a hydroxy metabolite. While the activity of the acid metabolite is negligible, the activity of the hydroxy metabolite is approximately 65% of the activity of the parent drug.

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