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重要文件

27525

Sigma-Aldrich

L-Citrulline 7-amido-4-methylcoumarin hydrobromide

≥98.0% (sum of enantiomers, HPLC)

同義詞:

L-Citrulline 4-methyl-7-coumarinylamide hydrobromide

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About This Item

經驗公式(希爾表示法):
C16H20N4O4 · HBr
CAS號碼:
分子量::
413.27
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:

品質等級

化驗

≥98.0% (sum of enantiomers, HPLC)

儲存溫度

2-8°C

SMILES 字串

Br[H].CC1=CC(=O)Oc2cc(NC(=O)[C@@H](N)CCCNC(N)=O)ccc12

InChI

1S/C16H20N4O4.BrH/c1-9-7-14(21)24-13-8-10(4-5-11(9)13)20-15(22)12(17)3-2-6-19-16(18)23;/h4-5,7-8,12H,2-3,6,17H2,1H3,(H,20,22)(H3,18,19,23);1H/t12-;/m0./s1

InChI 密鑰

XYOHUMXDURSJOW-YDALLXLXSA-N

應用

L-Citrulline 7-amido-4-methylcoumarin is used as a sensitive fluorogenic substrate for citrulline ureidase, yielding a blue solution upon cleavage.

其他說明

Substrate for proteases

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Manish Mahawar et al.
Journal of bacteriology, 191(15), 4798-4806 (2009-06-09)
The citrulline ureidase (CTU) activity has been shown to be associated with highly virulent Francisella tularensis strains, including Schu S4, while it is absent in avirulent or less virulent strains. A definitive role of the ctu gene in virulence and
J E Clarridge et al.
Journal of clinical microbiology, 34(8), 1995-2000 (1996-08-01)
We have isolated two phenotypically distinct nonfastidious Francisella strains (Fx1 and Fx2) from the blood of compromised patients with pneumonia and compared them with eight other Francisella strains, including Francisella tularensis biovar tularensis, F. tularensis biovar novicida, and F. philomiragia.
J E Sheppeck et al.
Bioorganic & medicinal chemistry letters, 10(23), 2639-2642 (2000-12-29)
A statistically exhaustive, 8800 compound tripeptidal amidomethylcoumarin library was synthesized as discreet compounds using solid-phase combinatorial chemistry. A subset of the compounds was purified by HPLC and tested in a high-throughput fluorometric assay against several known serine and cysteine proteases
N J MARCHETTE et al.
Journal of bacteriology, 82, 26-32 (1961-07-01)
Marchette, Nyven J. (University of Utah, Salt Lake City), and Paul S. Nicholes. Virulence and citrulline ureidase activity of Pasteurella tularensis. J. Bacteriol. 82:26-32. 1961.-The presence of a citrulline ureidase system in Pasteurella tularensis strains of high virulence, and its

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