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描述
C10H12N5O13P3SLi4
品質等級
化驗
87% (HPLC)
形狀
solid
分子量
Mr 539.2 (GTP-γ-S)
Mr 563.0 (GTP-γ-S-Li4)
成份
GDP, ≤12% HPLC
GMP, ≤1% HPLC
GTP, ≤2% HPLC
包裝
pkg of 10 mg
製造商／商標名
Roche
儲存條件
protect from light
濃度
97%
技術
activity assay: suitable
顏色
white
溶解度
water: soluble
儲存溫度
−20°C (−15°C to −25°C)
一般說明
鸟苷5′-O-(3-硫代三磷酸)四锂盐(GTP-γ-S)是GTP的不可水解类似物。它是光感受器中磷酸二酯酶的抑制剂。
應用
GTP-γ-S已用于：
- 在G蛋白激活检测中评估蛋白酶激活受体4(PAR4)的功能
- 用于G蛋白α亚基(Gα)的荧光法鸟嘌呤核苷酸交换测定
- 监测磷脂酶Cγ2突变体的Rac家族小鸟苷三磷酸酶（GTP酶）2 (Rac2)刺激活性
生化／生理作用
鸟苷5′-O-(3-硫代三磷酸)(GTP-γ-S)可激活鸟嘌呤-核苷酸结合蛋白，可通过酶法缓慢水解。它对鸟苷三磷酸酶（GTP酶）的抑制作用强于鸟苷三磷酸(GTP)。
儲存和穩定性
-15至-25°C环境下干燥储存粉末；pH值约为7。应在-15至-25°C下可稳定保存六个月。
分析報告
吸光度: 在水溶液中采用254nm吸光法测定含量。
条件：
条件：
- 约10 mg/ml双蒸水。
- 稀释度：9.8 ml双蒸水 + 0.2 ml样品。
其他說明
仅用于生命科学研究。不可用于诊断。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
does not flash
閃點（°C）
does not flash
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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S Nawy et al.
Neuron, 7(4), 677-683 (1991-10-01)
Transmitter release from photoreceptors is decreased by light, resulting in a conductance increase in depolarizing bipolar cells. Addition of exogenous cGMP through a patch pipette to depolarizing bipolar cells from slices of dark-adapted tiger salamander retina resulted in an enhancement
K Sasaki et al.
Nature, 325(6101), 259-262 (1987-01-15)
Recently, a GTP-binding protein sensitive to islet activating protein (IAP) has been suggested to be important in producing K+-currents when the muscarinic receptor of the atrial muscle is activated by acetylcholine (ACh). Here we confirm the blocking effects of IAP
Gilbert Di Paolo, Markus R. Wenk
Lipids, 3-18 (2012)
Stephen R Sprang
Biopolymers, 105(8), 449-462 (2016-03-22)
This review addresses the regulatory consequences of the binding of GTP to the alpha subunits (Gα) of heterotrimeric G proteins, the reaction mechanism of GTP hydrolysis catalyzed by Gα and the means by which GTPase activating proteins (GAPs) stimulate the
Alba Navarro-Romero et al.
eLife, 11 (2022-10-12)
Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular abnormalities. Nowadays, there are no pharmacological treatments to directly ameliorate the main traits of WBS. The
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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