推薦產品
生物源
rabbit
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
liquid
不包含
preservative
物種活性
mouse, human
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
avoid repeated freeze/thaw cycles
同型
IgG
運輸包裝
wet ice
儲存溫度
−70°C
目標翻譯後修改
unmodified
基因資訊
human ... TP53(7157)
一般說明
Purified rabbit polyclonal antibody. Recognizes the ~230 kDa 53BP1 protein.
Recognizes the ~230 kDa 53BP1 protein in HeLa cell nuclear extract (Cat. No. WB64).
This Anti-p53 Binding Protein 1 (Ab-1) Rabbit pAb is validated for use in Immunoblotting, Immunofluorescence, Immunoprecipitation for the detection of p53 Binding Protein 1 (Ab-1).
免疫原
Human
a recombinant protein consisting of human 53BP1 fused to a His•Tag sequence
應用
Immunoblotting (1:3000-1:5000)
Immunofluorescence (1:300-1:500, indirect)
Immunoprecipitation (1:300-1:500)
Immunofluorescence (1:300-1:500, indirect)
Immunoprecipitation (1:300-1:500)
包裝
Please refer to vial label for lot-specific concentration.
警告
Toxicity: Standard Handling (A)
外觀
In 100 mM NaCl, 50 mM Tris-HCl, 20% glycerol, pH 7.6.
重構
Following initial thaw, aliquot and freeze (-70°C).
分析報告
Positive Control
HeLa Cell Nuclear Extract (Cat. No. WB64)
HeLa Cell Nuclear Extract (Cat. No. WB64)
其他說明
Antibody should be titrated for optimal results in individual systems.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Mariana Acevedo et al.
Cancer research, 76(11), 3252-3264 (2016-05-22)
Promyelocytic leukemia (PML) plays a tumor suppressive role by inducing cellular senescence in response to oncogenic stress. However, tumor cell lines fail to engage in complete senescence upon PML activation. In this study, we investigated the mechanisms underlying resistance to
Mafuka Suzuki et al.
PloS one, 18(1), e0281168-e0281168 (2023-01-28)
Malignancy is often associated with therapeutic resistance and metastasis, usually arising after therapeutic treatment. These include radio- and chemo-therapies, which cause cancer cell death by inducing DNA double strand breaks (DSBs). However, it is still unclear how resistance to these
Haruka Fujimori et al.
Heliyon, 5(12), e03057-e03057 (2020-02-23)
Most cancers develop with one of two types of genomic instability, namely, chromosomal instability (CIN) or microsatellite instability (MSI). Both are induced by replication stress-associated DNA double-strand breaks (DSBs). The type of genomic instability that arises is dependent on the
Salma Akter et al.
Genes to cells : devoted to molecular & cellular mechanisms, 28(1), 53-67 (2022-11-24)
Steroid hormones induce the transcription of target genes by activating nuclear receptors. Early transcriptional response to various stimuli, including hormones, involves the active catalysis of topoisomerase II (TOP2) at transcription regulatory sequences. TOP2 untangles DNAs by transiently generating double-strand breaks
Atsuhiro Shimizu et al.
Biochemistry and biophysics reports, 16, 115-121 (2018-11-13)
Deamination of 5-methyl cytosine is a major cause of cancer-driver mutations in inflammation-associated cancers. The deaminase APOBEC3B is expressed in these cancers and causes mutations under replication stress; however, the mechanisms by which APOBEC3B mediates deamination and its association with
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