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Key Documents

NE1019

Sigma-Aldrich

抗-髓磷脂碱性蛋白小鼠单克隆抗体(SMI-99)

liquid, clone SMI-99, Calbiochem®

同義詞:

Myelin basic protein antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.43

生物源

mouse

品質等級

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

SMI-99, monoclonal

形狀

liquid

包含

≤0.1% sodium azide as preservative

物種活性

guinea pig (weakly), mammals

應無反應活性

chicken, porcine

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
avoid repeated freeze/thaw cycles

同型

IgG2b

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... MBP(4155)

一般說明

纯化的小鼠单克隆抗体。识别~21 kDa髓鞘碱性蛋白(MBP)。
识别大鼠脑组织中约21 kDa的髓鞘碱性蛋白。不识别14 kDa形式。识别大多数哺乳动物物种。
该抗髓鞘碱性蛋白小鼠单克隆抗体(SMI-99)经验证可用于ELISA、免疫印迹、免疫细胞化学、冷冻切片、石蜡切片以检测髓鞘碱性蛋白。

免疫原

人髓鞘碱性蛋白
表位:氨基酸131-136内

應用


ELISA(1:1000)
免疫印迹法(1:1000)
免疫细胞化学(1:1000)
冷冻切片(1:1000)
石蜡切片(1:1000)

警告

毒性:标准处理(A)

其他說明

Evers, P. and Uylings, H.B.1997.J. Neurosci. Methods72, 197.
Shin, R.W., et al. 1991.Lab. Invest.64, 693.
识别大多数哺乳动物物种的MBP。不能识别~14 kDa形式的MBP。检测发育中和成人髓鞘和发育中的少突胶质细胞。还可以区分少突胶质细胞与星形胶质细胞、小胶质细胞、神经元以及脑组织切片中的其他细胞。与抗髓鞘碱性蛋白小鼠单克隆抗体(SMI-91)(目录号NE1020)和/或抗髓鞘碱性蛋白小鼠单克隆抗体(SMI-94)(目录号NE1018)结合,该抗体可用于正常和病理性髓鞘形成进展的免疫细胞化学研究。在单个系统中,应对抗体进行滴定以获得最佳结果。

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Jane L Zhu et al.
Journal of translational medicine, 20(1), 41-41 (2022-01-26)
Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined. Autoantigen microarray was used to profile autoantibodies from the serum
Gerben van Hameren et al.
Acta neuropathologica communications, 7(1), 86-86 (2019-06-13)
Mitochondria are critical for the function and maintenance of myelinated axons notably through Adenosine triphosphate (ATP) production. A direct by-product of this ATP production is reactive oxygen species (ROS), which are highly deleterious for neurons. While ATP shortage and ROS
L N Collins et al.
The Journal of comparative neurology, 526(11), 1843-1858 (2018-04-18)
Both the lateral olfactory tract (LOT) and anterior limb of the anterior commissure (AC) carry olfactory information. The LOT forms the projection from the olfactory bulb to the ipsilateral olfactory cortices, while the AC carries odor information across the midline
Taasin Srivastava et al.
The Journal of clinical investigation, 128(5), 2025-2041 (2018-04-18)
Cerebral white matter injury (WMI) persistently disrupts myelin regeneration by oligodendrocyte progenitor cells (OPCs). We identified a specific bioactive hyaluronan fragment (bHAf) that downregulates myelin gene expression and chronically blocks OPC maturation and myelination via a tolerance-like mechanism that dysregulates
S M Bhagat et al.
Molecular psychiatry, 21(9), 1281-1289 (2015-12-02)
Critical periods are temporary windows of heightened neural plasticity early in development. For example, fear memories in juvenile rodents are subject to erasure following extinction training, while after closure of this critical period, extinction training only temporarily and weakly suppresses

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