MABT394

Anti-Plakophilin-2 Antibody, clone 8H6

clone 8H6, from mouse

• 同義詞: Plakophilin-2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 8H6, monoclonal
• 物種活性: human
• 技術: immunocytochemistry: suitable; western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_004563
• UniProt登錄號: Q99959
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PKP2(5318)

描述

一般說明

Plakophilin-2 (PKP2) is a member of the Armadillo/β-catenin family. It contains eight ARM repeats and can exist in two slice isoforms (2a and 2b). Plakophilin-2 is highly abundant in simple and stratified epithelial cells; but is also expressed in non-epithelial cells, such as the myocardium and lymph node follicles. In epithelial cells, it is localized to desmosomal plaques and plays an important role in cell-cell adhesion processes. Plakophilin-2 also maintains the cell-cell junctions of cardiac tissue, and is essential for proper cardiac function. Mutations in the plakophilin-2 gene cause arrhythmogenic right ventricular cardiomyopathy 9, a condition characterized by partial breakdown of the myocardium of the right ventricle, electrical instability, and sudden death. Plakophilin-2 has also been implicated in the development of cancer.

免疫原

MBP-tagged recombinant protein corresponding to human Plakophilin-2.

應用

Anti-Plakophilin-2 Antibody, clone 8H6 detects level of Plakophilin-2 & has been published & validated for use in Western Blotting, ICC.

Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in A431 and UM-SCC-38 cells. (Sobolik-Delmaire, T., et al. (2010). Journal of Investigative Dermatology. 130:2638–2646.)

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

品質

Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Plakophilin-2 in 10 µg of A431 cell lysate.

標靶描述

~97 kDa observed

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
A431 cell lysate

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable