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Key Documents

MABT27

Sigma-Aldrich

Anti-LIBS2 epitope (Integrin beta3 subunit) Antibody, clone ab62

clone ab62, from mouse

同義詞:

LIBS2 domain, Integrin, Integrin alphaVbeta3, LIBS2 epitiope

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

ab62, monoclonal

物種活性

human

技術

flow cytometry: suitable
western blot: suitable

同型

IgG2aκ

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... ITGB3(3690)

一般說明

The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The adhesion receptor, integrin alphaVbeta3, appears to be selectively expressed on growing blood vessels and has been identified as a marker of angiogenic vascular tissue.
Clone Ab62 is a monoclonal antibody that specifically recognizes the LIBS2 epitope in the C-terminal region of the extracellular domain of the beta3 subunit (Wiberzbicka-Patynowski, I., et al. (1999). JBC. 274(53):37809-37814).

特異性

This antibody recognizes the LIBS2 epitope in the C-terminal region of the extracellular domain of the beta3 subunit of integrins.

免疫原

Epitope: LIBS2 epitope in the C-terminal region of the extracellular domain of the beta3 subunit of integrins.
Human GPIIa-IIIb purified from platelets

應用

Anti-LIBS2 epitope (Integrin beta3 subunit) Antibody, clone ab62 is an antibody against LIBS2 epitope (Integrin beta3 subunit) for use in WB, FC.
Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC (Ginsberg, M., et al. (1990). Blood. 76:2017-2023.)
Research Category
Cell Structure
Research Sub Category
Integrins

品質

Evaluated by Western Blot in human platelets cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected LIBS2 domain of integrin beta3 subunit in 10 µg of human platelets cell lysate.

標靶描述

~110 kDa observed in human platelets.
Other MW bands may vary or may be observed depending on lysate used and if the LIBS2 epitope is present in other proteins.

外觀

Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human platelets cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Wen-Ye Tjong et al.
Scientific reports, 9(1), 1517-1517 (2019-02-08)
CD97/ADGRE5 is an adhesion G protein-coupled receptor (aGPCR) involved in tumor cell adhesion, migration, angiogenesis, and apoptosis. CD97 has been shown previously to stimulate angiogenesis by interacting with integrins on endothelial cells via an Arginine-Glycine-Aspartic acid (RGD) motif. In this

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