MABS186

Anti-LOX-1, clone 9E12.1

clone 9E12.1, from mouse

• 同義詞: LOX-1, Oxidized low-density lipoprotein receptor 1, Ox-LDL receptor 1, C-type lectin domain family 8 member A, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, hLOX-1, Lectin-type oxidized LDL receptor 1, Oxidized low-density lipoprotei
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 9E12.1, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG2aκ
• NCBI登錄號: NP_001166103
• UniProt登錄號: P78380
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... OLR1(4973)

描述

一般說明

LOX1 is a plasma membrane receptor, that also has a free soluble receptor form, that is the receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. LOX1 is also the receptor for HSP70, and LOX1 acts as a leukocyte adhesion molecule on glycosylated proteins present on platelets, monocytes, bacteria, apoptotic cells in inflammatory responses.

免疫原

GST-tagged recombinant protein corresponding to human LOX-1.

應用

Anti-LOX-1 Antibody, clone 9E12.1 is an antibody against LOX-1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LOX-1 in human placenta tissue.

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

品質

Evaluated by Western Blotting in KG-1 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected LOX-1 in 200 µg of KG-1 cell lysate.

標靶描述

~35 kDa observed. The calculated molecular weight of this protein is 31 kDa, but can be observed at ~33-37 kDa due to high glycosylation.

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable