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重要文件

MABS1147

Sigma-Aldrich

Anti-SH2D1A Antibody, clone SuGr-20 18A9

clone SuGr-20 18A9, from mouse

同義詞:

SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
無性繁殖:
SuGr-20 18A9, monoclonal
application:
WB
物種活性:
human
技術:
western blot: suitable
citations:

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

SuGr-20 18A9, monoclonal

物種活性

human

技術

western blot: suitable

同型

IgG2bκ

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... SH2D1A(4068)

一般說明

SH2 domain-containing protein 1A (UniProt O60880; also known as Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP) is encoded by the SH2D1A (also known as DSHP, SAP, XLP, XLP1, XLPD) gene (Gene ID 4068) in human. SAP/SH2D1A is a 628-amino acid (isoform A) adaptor protein expressed in T cells, natural killer (NK) cells, NK-T cells, and some B cells. SAP/SH2D1A is made up almost exclusively of a Src homology 2 (SH2) domain (a.a. 6-104) and plays an important role in multiple immune cell functions, including T helper 2 (TH2) cytokine production, T cell-dependent antibody production, follicular T helper (TFH) cell differentiation, NK-T cell development, CD8+ T cell- and NK cell-mediated cytotoxicity. SAP couples signaling lymphocytic activation molecule (SLAM) family receptors to tyrosine phosphorylation signals through its interaction with the SH3 domain of Src family protein tyrosine kinase Fyn. In addition, SAP can prevent SH2 domain-containing negative regulators, such as phosphatases SHIP-1 and SHP-1, from inactivating SLAM-related receptors by blocking their interaction with the receptors. Evidence also shows that SAP/SH2D1A regulates T cell-dependent antibody production and TFH cell differentiation independent of Fyn. SAP/SH2D1A gene is mutated and inactivated in X-linked lymphoproliferative disease, a rare human immunodeficiency characterized by an uncontrolled immune response to Epstein-Barr virus infection.

特異性

Clone SuGr-20 18A9 recognizes recombinant full-length human SH2D1A spliced isoform A (UniProt O60880-1) by Western blotting. Reactivity toward spliced isoforms B to F (UniProt O60880-2 to O60880-6) has not been determined.

免疫原

Recombinant full-length human SH2D1A.

應用

Anti-SH2D1A Antibody, clone SuGr-20 18A9 is an antibody against SH2D1A for use in Western Blotting.
Research Category
Signaling
Research Sub Category
Immunological Signaling

品質

Evaluated by Western Blotting of recombinant human SH2D1A.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected 0.1 µg of recombinant human SH2D1A.

標靶描述

~14 kDa observed. 14.19 kDa calculated.

外觀

Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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