MABN263

Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8

clone 10F10-C1-B8, from mouse

• 同義詞: Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 無性繁殖: 10F10-C1-B8, monoclonal
• application: ICC; WB
• 物種活性: rat
• 技術: immunocytochemistry: suitable; western blot: suitable
• citations: 1

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 10F10-C1-B8, monoclonal
• 物種活性: rat
• 技術: immunocytochemistry: suitable; western blot: suitable
• 同型: IgG2bκ
• NCBI登錄號: NP_899156
• UniProt登錄號: P18508
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: rat ... Gabrg2(29709)

描述

一般說明

GABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.

免疫原

Linear peptide corresponding to rat GABA(A) receptor subunit gamma-2.

應用

Detect GABA(A) receptor subunit gamma-2 using this Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8 validated for use in Western Blotting, ICC.

Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected GABA(A) receptor subunit gamma-2 in rat hippocampal neurons. Image courtesy from the laboratory of Dr. Jaideep Kapur, University of Virginia.

品質

Evaluated by Western Blot in PC-12 cell lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 in 10 µg of PC-12 cell lysate.

標靶描述

~54 kDa observed

外觀

Format: Purified

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable