MABF390

Anti-CD152 (CTLA-4) Antibody (mouse), PE, clone UC10-4F10-11

clone UC10-4F10-11, 0.2 mg/mL, from hamster(Armenian)

• 同義詞: Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: hamster (Armenian)
• 品質等級: 100
• 共軛: PE
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: UC10-4F10-11, monoclonal
• 物種活性: mouse
• 濃度: 0.2 mg/mL
• 技術: flow cytometry: suitable
• 同型: IgG
• UniProt登錄號: P09793
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Ctla4(12477)

描述

一般說明

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

免疫原

Immunogen information for this antibody is proprietary information.

應用

Research Category
Inflammation & Immunology

This armenian hamster monoclonal antibody Anti-CD152 (CTLA-4) (mouse), PE & clone UC10-4F10-11 validated for use in Flow Cytometry for the detection of CD152 (CTLA-4).

品質

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 µg of this antibody detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.

外觀

Size Exclusion Chromatography

Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

儲存和穩定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable