MABF153E

Anti-CD8a (Mouse), clone 53-6.7, biotin conjugate Antibody

clone 53-6.7, from rat, purified by affinity chromatography

• 同義詞: T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, CD8a
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.45

屬性

• 生物源: rat
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 53-6.7, monoclonal
• 純化經由: affinity chromatography
• 物種活性: mouse
• 包裝: antibody small pack of 25 μg
• 技術: flow cytometry: suitable
• UniProt登錄號: P01731
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Cd8A(12525)

描述

一般說明

The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

應用

Anti-CD8a (Mouse), clone 53-6.7, biotin conjugate Antibody detects level of CD8a and has been published and validated for use in Flow Cytometry.

品質

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD8a in one million C57Bl/6 splenocytes.

其他說明

Concentration: Please refer to lot specific datasheet.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: nwg