MABF148D

Anti- CD161 (NK1.1) (mouse), APC, clone PK136 Antibody

clone PK136, from mouse, Allophycocyanin conjugate

• 同義詞: Killer cell lectin-like receptor subfamily B member 1B allele A, CD161 antigen-like family member B, Lymphocyte antigen 55b (Ly-55b), NKR-P1 34, Natural killer cell surface protein NKR-P1B allele SJL/BALB (NKR-P1B), CD161b, CD161 (NK1.1)
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 共軛: Allophycocyanin conjugate
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: PK136, monoclonal
• 物種活性: mouse
• 包裝: antibody small pack of 25 μg
• 技術: flow cytometry: suitable
• 同型: IgG2aκ
• UniProt登錄號: P27812
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Klrb1C(17059)

描述

一般說明

The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247).The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).

免疫原

Immunogen information for this antibody is proprietary information.

應用

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

This mouse monoclonal Anti- CD161 (NK1.1) Antibody (mouse), APC, clone PK136, Cat. No. MABF1488 is validated for use in Flow Cytometry, for the detection of CD161 (NK1.1).

品質

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD161 (NK1.1) in one million C57Bl/6 splenocytes stained with FITC Anti-mouse CD3e.

外觀

Purified by size-exclusion chromatography

Purified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.
Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable