MABC730

Anti-SCARB1 Antibody, clone 5B8.2

clone 5B8.2, 1 mg/mL, from mouse

• 同義詞: Scavenger receptor class B member 1, SRB1, CD36 and LIMPII analogous 1, CLA-1, CD36 antigen-like 1, Collagen type I receptor, thrombospondin receptor-like 1, SR-BI, CD36
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 無性繁殖: 5B8.2, monoclonal
• application: IHC; WB
• 物種活性: human
• 技術: immunohistochemistry: suitable; western blot: suitable
• citations: 1

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 5B8.2, monoclonal
• 物種活性: human
• 濃度: 1 mg/mL
• 技術: immunohistochemistry: suitable; western blot: suitable
• 同型: IgMκ
• NCBI登錄號: NP_005496
• UniProt登錄號: Q8WTV0
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SCARB1(949)

描述

一般說明

Scavenger receptor class B member 1 (SCARB1), or CD36L1, is the membrane bound cell surface receptor for high density lipoprotein (HDL) as well as a number of related compounds such as phospholipids, cholesterol ester, and phosphatidylserine and apoptotic cells (via their expression of phosphatidylserine on their extracellular surfaces). SCARB1 is also the receptor for Hepatitis C virus glycoprotein E2 and it facilitates the attachment and entry of HCV. SCARB1 plays a critical role in cholesterol homeostasis and mediates cholesterol transfer to and from the HDL protein carriers, a process known as reverse cholesterol transport. It is highly expressed in tissues that require free cholesterol such as the liver and steroidogenic tissues (adrenals, testis, ovary). SCARB1 expression has also been associated with particular cancers including chronic myeloid leukemia (CML), breast cancer, bladder carcinoma, and prostate cancer.

免疫原

Epitope: Extracellular domain

KLH-conjugated linear peptide corresponding to the extracellular domain of human SCARB1.

應用

Detect SCARB1 using this Anti-SCARB1 Antibody, clone 5B8.2 validated for use in western blotting & IHC.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SCARB1 in human adrenal gland tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Western Blotting in human adrenal tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SCARB1 in 10 µg of human adrenal tissue lysate.

標靶描述

~61 kDa observed. Uncharacterized band(s) may appear in some lysates.

外觀

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable