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一般說明
Lipoprotein lipase (LPL) is encoded by the LPL/LIPD gene in humans and is a lipase that localizes to the plasma membrane of the microvilli of hepatocytes and the luminal surface of endothelial cells in capillaries. It is expressed in a wide variety of tissues from fat and heart to muscle and mammary glands. It can also be found in the blood bound to lipoproteins. Its function is to hydrolyze triglycerides from the blood and other sources into free fatty acids; LPL also acts as receptor and binding factor for lipoprotein uptake and allows for the catalysis of VLDL from the blood. Expression and regulation of LPL differ by tissue type, some factors such as insulin can stimulate LPL expression in fat tissues, where as insulin down regulates LPL expression on muscle. Recently because serum triglyceride levels are linked with the development of cancer, LPL has become a target for cancer prevention and therapy because LPL catalyzes plasma triglycerides leading to lower levels, it is thought that LPL assisted therapy could be useful in preventing or treating cancers. EMD-Millipore’s Anti-LPL mouse monoclonal antibody has been tested on western blots using HeLa cell lysates.
免疫原
Purified recombinant fragment of human LPL expressed in E. Coli.
應用
Anti-LPL Antibody, clone 2C5 is a mouse monoclonal antibody & validated for use in western blotting.
品質
Evaluated by Western Blotting in Hela cell lysate.
Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected LPL in Hela cell lysate.
Optimal working dilutions must be determined by end user.
Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected LPL in Hela cell lysate.
Optimal working dilutions must be determined by end user.
標靶描述
~53 kDa observed
分析報告
Control
Hela cell lysate
Hela cell lysate
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Charlotte H Hulme et al.
Scientific reports, 9(1), 14114-14114 (2019-10-03)
Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect
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