MABC573

Anti-Bcl-2 Antibody, clone 1D7.2

clone 1D7.2, from rat

• 同義詞: Apoptosis regulator Bcl-2, Bcl-2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702

屬性

• 生物源: rat
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 1D7.2, monoclonal
• 物種活性: mouse
• 技術: western blot: suitable
• 同型: IgG2aκ
• NCBI登錄號: NP_033871
• UniProt登錄號: P10417
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Bcl2(12043)

描述

一般說明

Apoptosis regulator Bcl-2 (UniProt P10417; also known as B-cell leukemia/lymphoma 2) is encoded by the Bcl2 (also known as Bcl-2, AW986256, C430015F12Rik, D630044D05Rik, D830018M01Rik) gene (Gene ID 12043) in murine species. Bcl-2 is an anti-apoptotic and the founding member of the Bcl-2 family of proteins that paly either a pro- or anti-apoptotic role in cell death signaling. BCL-2 family members are related by regions of sequence and structural homology. The pro-survival members contain four BCL-2 homology regions (BH1–BH4), whereas the BH3-only members contain only the BH3 amphipathic helix, which mediates their interaction with the groove of multi-domain BCL-2 family members. Human BCL2 gene mutatons are well known causes of many cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer.

特異性

Expected to react with both spliced isoforms of murine Bcl-2.

免疫原

Epitope: N-terminal half

GST-tagged recombinant protein corresponding to the N-terminal of mouse Bcl-2.

應用

Detect Bcl-2 using this rat Monoclonal Anti-Bcl-2 Antibody, clone 1D7.2, Cat. No. MABC573, validated for use in Western Blotting.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Western Blotting in mouse myoblast C2C12 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Bcl-2 in 10 µg of mouse myoblast C2C12 cell lysate.

標靶描述

~22 kDa observed (26.4 kDa/isoform 1 & 22.3 kDa/isoform 2, calculated).

外觀

Protein G Purified

Format: Purified

Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable