MABC552

Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1

clone 11C7.1, from mouse

• 同義詞: Kallikrein-1, Kidney/pancreas/salivary gland kallikrein, Tissue kallikrein, Kallikrein-1/KLK1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 11C7.1, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG2bκ
• NCBI登錄號: NP_002248
• UniProt登錄號: P06870
• 運輸包裝: dry ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... KLK1(3816)

描述

一般說明

Kallikrein-1 (EC:3.4.21.35; UniProt P06870; also known as Glandular kallikrein 1, hK1, Kallikrein serine protease 1, Kidney/pancreas/salivary gland kallikrein, Renal/pancreas/salivary kallikrein 1, Tissue kallikrein) is encoded by the KLK1 (also known as KLKR) gene (Gene ID 3816) in human. Kallikrein-1 is a member of the kallikrein subfamily of serine proteases, members of which are involved in diverse physiological functions and many are used clinically as biomarkers for cancer. Kallikrein-1 is initially produced as a preproprotein with a signal (aa 1-18) and a propeptide (aa 19-24), cleavage of which releases the mature protein (aa 25-262). Kallikrein-1 is the major kallikrein expressed in the kidney, where it generates kinins (e.g. lysyl-bradykinin and bradykinin) and plays role in kidney function and blood pressure regulation through vasodilatory and natriuretic effects. Decreased kidney Kallikrein-1 level is reported in experimental settings of hypertension, diabetic nephropathy, high salt- and aminoglycoside-induced kidney injury.

免疫原

GST-tagged recombinant protein corresponding to the C-terminal half of human Kallikrein-1/KLK1.

應用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein-1/KLK1 in human pancreas and human colon tissue.

This Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Kallikrein-1/KLK1.

品質

Evaluated by Western Blotting in human salivary gland tissue lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Kallikrein-1/KLK1 in 10 µg of human salivary gland tissue lysate.

標靶描述

~30 kDa observed. 28.9 kDa/isoform 1 and 23.8 kDa/isoform 2 calculated.

外觀

Format: Purified

其他說明

Concentration: Please refer to lot specific datasheet.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable