MABC545

Anti-FANCM Antibody, clone CV5.1

clone CV5.1, 0.5 mg/mL, from mouse

• 同義詞: Fanconi anemia group M protein, Protein FACM, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: CV5.1, monoclonal
• 物種活性: human
• 濃度: 0.5 mg/mL
• 技術: immunocytochemistry: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_065988
• UniProt登錄號: Q8IYD8
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... FANCM(57697)

描述

一般說明

FANCM, also known as Fanconi anemia group M protein (FACM), or ATP-dependent RNA helicase FANCM, or Fanconi anemia-associated polypeptide of 250 kDa (FAAP250), or Protein Hef ortholog, and encoded by the gene FANCM/KIAA1596,is a critical ATPase needed for proper DNA repair. FANCM is found at DNA replication forks and required for cellular resistance to DNA cross-linking agents and for proper DNA repair. FANCM belongs to a multi-subunit FA (Fanconi anemia) complex. FANCM is localized to the nucleus and expressed in most cells. Defects in FANCM may be associated with Fanconi anemia complementation group M (FANCM) a disorder affecting hematopoietic cells can causing anemia, leukopenia and thrombopenia. Patients also have cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition toward malignancies. Patient’s cells show hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.

免疫原

His-tagged recombinant protein corresponding to human FANCM.

應用

Detect FANCM using this Anti-FANCM Antibody, clone CV5.1 validated for use in ICC.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Immunohistochemistry Analysis in A431, HeLa, and HepG2 cells.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected FANCM in A431, HeLa, and HepG2 cells.

Dylight^® is a registered trademark of Thermo Fisher Scientific.

標靶描述

230 kDa calculated

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

法律資訊

DyLight is a registered trademark of Pierce Biotechnology, Inc.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable