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Merck
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重要文件

MAB5276

Sigma-Aldrich

Anti-Endorphin β Antibody, clone 3-E7

clone 3-E7, Chemicon®, from mouse

同義詞:

Anti-ACTH

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

3-E7, monoclonal

物種活性

pig, human

製造商/商標名

Chemicon®

技術

ELISA: suitable
immunohistochemistry: suitable

同型

IgG2a

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... POMC(5443)

特異性

The antibody reacts with the amino terminal H-Tyr-Gly-Gly-Phe sequence of human O-endorphin. Therefore, a high cross-reactivity with homologues of identical sequence, such as [Met]-enkephalin and [Leu]-enkephalin and a number of opioid peptides, occurs; the antibody also reacts with swine and camel O-endorphin. However, the antibody does not recognize human beta-lipotropin and N-acetyl-beta-endorphin (Gramsch et al., 1983; Meo et al., 1983; Herz et al., 1982).

免疫原

Synthetic human beta-endorphin coupled with poly-lysine or thyroglobulin (Gramsch et al., 1983; Meo et al., 1983) (H-Tyr-Gly-Gly-Phe sequence).

應用

ELISA Immunohistochemistry

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neuroinflammation & Pain

Hormones & Receptors
This Anti-Endorphin Antibody, β, clone 3-E7 is validated for use in ELISA, IH for the detection of Endorphin.

外觀

Format: Purified
Purified immunoglobulin. Liquid in 0.02M Phosphate buffer with 0.25M NaCl and 0.1% sodium azide.

儲存和穩定性

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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Binding characteristics of a monoclonal beta-endorphin antibody recognizing the N-terminus of opioid peptides.
Gramsch, C, et al.
Journal of Neurochemistry, 40, 1220-1226 (1983)
W H Oertel et al.
Life sciences, 33 Suppl 1, 73-76 (1983-01-01)
Opioid peptide-like (OPL)-immunoreactivity and (the GABA-biosynthetic enzyme) glutamic acid decarboxylase-like (GAD)-immunoreactivity were localized in rat neostriatum and central amygdaloid nucleus (ACE) using a polyclonal sheep antiserum to rat brain GAD and a monoclonal mouse antibody to the N-terminus of beta-endorphin
Fernanda B Lima et al.
Brain research, 1663, 1-8 (2017-03-13)
With the decline of ovarian steroids levels at menopause, many women experience an increase in anxiety and stress sensitivity. The locus coeruleus (LC), a central source of noradrenaline (NE), is activated by stress and is inhibited by β-endorphin. Moreover, increased
Characteristics of a monoclonal beta-endorphin antibody recognizing the N-terminus of opioid peptides.
Herz, A, et al.
Life Sciences, 31, 1721-1724 (1982)
Monoclonal antibody to the message sequence Tyr-Gly-Gly-Phe of opioid peptides exhibits the specificity requirements of mammalian opioid receptors.
Meo, T, et al.
Proceedings of the National Academy of Sciences of the USA, 80, 4084-4088 (1983)

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