MAB3418B

Anti-MAP2 Antibody, clone AP20, Biotin Conjugated

clone AP20, from mouse, biotin conjugate

• 同義詞: Microtubule-associated protein 2, MAP-2, MAP2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 共軛: biotin conjugate
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: AP20, monoclonal
• 物種活性: rat
• 物種活性（以同源性預測）: bovine (immunogen homology), mouse (based on 100% sequence homology), chicken (based on 100% sequence homology), human (based on 100% sequence homology)
• 技術: immunocytochemistry: suitable
• 同型: IgG
• UniProt登錄號: Q0IIA8
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: chicken ... Map2(424001) ; human ... MAP2(4133) ; mouse ... Map2(17756) , Map2(281294) ; rat ... Map2(25595)

描述

一般說明

The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules (Herzog and Weber, 1978), and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.

免疫原

Bovine brain microtubule protein

應用

Anti-MAP2 Antibody, clone AP20, Biotin Conjugated is an antibody against MAP2 for use in ICC.

Immunocytochemistry Analysis: A 1:25 dilution from a representative lot detected MAP2 in rat E18 primary cortex cells.

品質

Evaluated by Immunohistochemistry in rat cortex tissue.

Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected MAP2 in rat cortex tissue.

標靶描述

The unconjugated parent antibody (Cat. No. MAB3418) has an observed molecular weight at ~230 kDa

外觀

Purified mouse monoclonal IgG conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable