MAB2641

Anti-Fibrillin (Pan) Antibody, clone 689

clone 689, from mouse

• 同義詞: EGF-containing fibulin-like extracellular matrix protein 1, Fibrillin-like protein, Extracellular protein S1-5
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 689, monoclonal
• 物種活性: mouse
• 物種活性（以同源性預測）: chicken (based on 100% sequence homology), human (based on 100% sequence homology)
• 技術: ELISA: suitable; immunohistochemistry: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_115823
• UniProt登錄號: Q75N90
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... EFEMP1(2202)

描述

一般說明

Fibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.

特異性

The antibody recognizes isoforms 1, 2, and 3 of fibrillin.

免疫原

Recombinant protein corresponding to human Fibrillin 3.

應用

Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.

ELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).

品質

Evaluated by Immunohistochemistry in fresh frozen mouse skin tissue.

Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.

標靶描述

~ 350 kDa calculated

外觀

Format: Purified

分析報告

Control
Mouse skin tissue

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable