MAB2616

Anti-Kindlin-1 Antibody, clone 4A5.14

clone 4A5.14, from mouse

• 同義詞: Kindlin syndrome protein, UNC-112 related protein 1, Unc-112-related protein 1, chromosome 20 open reading frame 42, kindlin 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 4A5.14, monoclonal
• 物種活性: human
• 技術: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• 同型: IgG2aκ
• NCBI登錄號: NP_060141
• UniProt登錄號: Q9BQL6
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... FERMT1(55612)

描述

一般說明

The Kindlin family is a group of focal adhesion proteins that have recently become a point of interest because of their ability to bind and activate integrins. Abnormalities in this ability have linked Kindlin to several diseases, both inherited and acquired, such as Kindler syndrome, cancer, and leukocyte adhesion deficiency. Specifically associated with Kindler syndrome, is the isoform Kindlin-1 which plays a key role in adhering the actin cytoskeleton to the extracellular matrix of basal keratinocytes. Kindlin-1 may also be involved in tumor growth by modulating TGF-beta 1 signaling (Shi, 2007). It is most widely expressed in the brain, kidney, colon, placenta, skeletal muscle, adrenal gland, and prostate.

特異性

The antibody recognizes Kindlin-1.

免疫原

Epitope: Unknown

GST-tagged recombinant protein corresponding to human Kindlin-1.

應用

Anti-Kindlin-1 Antibody, clone 4A5.14 is an antibody against Kindlin-1 for use in WB, IC, IH.

Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Papachristou, D.J., et al. (2007). Histopathology. 51(4):499–508.)

Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Papachristou, D.J., et al. (2007). Histopathology. 51(4):499–508.)

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

品質

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/ml of this antibody detected Kindlin-1 in 10 µg of HeLa cell lysate.

標靶描述

~ 70 kDa

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
HeLa cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable