推薦產品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
6B4, monoclonal
物種活性
human
製造商／商標名
Chemicon®
技術
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... ITGA6(3655)
一般說明
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrin function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha 3 and alpha6, two cytoplasmic variants, A and B, have been identified.
特異性
MAB1358 recognizes specifically the cytoplasmic domain of integrin subunit alpha 6B. The antibody stains the basement membrane zone of ducts and acini of salivary gland, kidney tubules, epithelium of colonic crypts and weakly stains sweat glands and sebaceous glands.
Broad species reactivity is expected due to the conserved nature of the epitope.
Broad species reactivity is expected due to the conserved nature of the epitope.
免疫原
Synthetic Peptide to the cytoplasmic domain of integrin subunit alpha6B including an appending N-terminal cysteine: CSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKK
應用
Anti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4 is an antibody against Integrin α6B for use in WB, IC, IH.
Western blotting: 1:100-1:500
Immunocytochemistry: 1:100-1:500 on frozen sections, 1:50-1:100 with avidin-biotin complex detection
Immunocytochemistry
Optimal working dilutions must be determined by the end user.
Immunocytochemistry: 1:100-1:500 on frozen sections, 1:50-1:100 with avidin-biotin complex detection
Immunocytochemistry
Optimal working dilutions must be determined by the end user.
外觀
Format: Purified
儲存和穩定性
Store at 2-8°C, or -20°C in small aliquots for up to 12 months after date of receipt. Avoid freeze/thaw cycles.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
未找到適合的產品？
試用我們的產品選擇工具.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Darcie D Seachrist et al.
The Journal of biological chemistry, 295(33), 11707-11719 (2020-06-25)
The phenotypes of each breast cancer subtype are defined by their transcriptomes. However, the transcription factors that regulate differential patterns of gene expression that contribute to specific disease outcomes are not well understood. Here, using gene silencing and overexpression approaches
Reconstruction of a human hemicornea through natural scaffolds compatible with the growth of corneal epithelial stem cells and stromal keratocytes.
Barbaro, V; Ferrari, S; Fasolo, A; Ponzin, D; Di Iorio, E
Molecular Vision null
Seo-Hyun Choi et al.
Molecular cancer research : MCR, 20(8), 1305-1319 (2022-04-09)
KRAS mutation in colorectal cancer is associated with aggressive tumor behavior through increased invasiveness and higher rates of lung metastases, but the biological mechanisms behind these features are not fully understood. In this study, we show that KRAS-mutant colorectal cancer
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務