IL029

Interleukin-12 Protein, Recombinant human

The recombinant human Interleukin-12 protein (or IL-12 protein) is a potent regulator of cell mediated immune responses & it induces IFN-gamma production by NK & T cells.

• 同義詞: IL-12
• 分類程式碼代碼: 12352202
• eCl@ss: 32160405
• NACRES: NA.77

屬性

• 生物源: human
• 品質等級: 100
• 重組細胞: expressed in CHO cells
• 化驗: >98% (SDS-PAGE and HPLC)
• 比活性: ≥1.0 x 10E6 U/mg
• 製造商／商標名: Chemicon^®
• 技術: cell culture | mammalian: suitable
• 雜質: <0.1 ng/μg endotoxin (of IL-12; 1EU/μg)
• 輸入: sample type hematopoietic stem cell(s)
• UniProt登錄號: P29459; P29460
• 運輸包裝: dry ice

描述

一般說明

Interleukin-12 (IL-12) is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Human IL-12 is a disulfide linked heterodimeric protein with a molecular weight of 75 kDa comprised of disulfide-bonded 35 kDa (p35) and 40 kDa (p40) subunits.

Product Source: CHO cells (Chinese Hamster Ovarian cells)

應用

For most in vitro applications, IL-12 exerts its biological activity in the concentration range of 1.0 to 10.0 ng/mL.

生化／生理作用

The ED50 as determined by the induction of IFN-g production from NK cells co-stimulated with IL-18 was ≤ 1.0 ng/mL

外觀

The sterile filtered solution was lyophilized from 0.5X PBS pH 7.2

儲存和穩定性

The lyophilized IL-12, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 0.2 mg/mL. Reconstituted IL-12 should be stored in undiluted aliquots at -20°C for up to 6 months.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3