GF170

DKK-1 Protein, Human Recombinant

The Dickkopf related protein 1 (or Dkk1 protein) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4 & a related protein, Soggy.

• 同義詞: Dickkopf related protein 1, DKK1, DKK, SK
• 分類程式碼代碼: 12352202
• eCl@ss: 32160405
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: >97% (SDS-PAGE and HPLC)
• 雜質: <0.1 μg/mg protein endotoxin (<1EU/μg)
• UniProt登錄號: O94907
• 運輸包裝: dry ice

描述

一般說明

Dickkopf related protein 1 (Dkk1) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4, and a related protein, Soggy. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.

Product Source: HEK293 Cells

特異性

Cross Reactivty
None

應用

Research Category
Stem Cell Research

Research Sub Category
Growth Factors & Receptors

品質

Bioactivity assay: Determined by its ability to inhibit the proliferation of HCT116 colorectal carcinoma cells. Approximately 40% growth inhibition was achieved at a DKK-1 concentration of 200ng/ml.

外觀

Product is filtered through a 0.2 micron filter before lyophilization.

儲存和穩定性

Store at -20°C for up to 6 months from date of receipt.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3