ABT22

Anti-Endophilin-A1 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: SH3-domain GRB2-like 2, bA335L15.1 (SH3-domain GRB2-like 2), Endophilin A1 BAR domain, SH3 domain protein 2A, Endophilin-1, SH3 domain-containing GRB2-like protein 2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse, rat
• 技術: western blot: suitable
• 同型: IgG
• NCBI登錄號: NP_062408
• UniProt登錄號: Q62420
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Sh3Gl2(20404)

描述

一般說明

A member of the Endophilin family, Endophilin A1 is a protein containing SH3 domains, and has been implicated in the trafficking of clathrin-mediated synaptic vesicle endocytosis within the membrane. It was originally characterized as a presynaptically enriched protein that binds to endocytic proteins polyphosphoinositide synaptojanin and dynamin. Endophilin A1 has been implicated in endocytic vesicle budding when its function in cell-free systems and in living synapses has been disturbed. Along with the SH3 domain, Endophilin A1 contains a BAR domain in the N-terminal region, that has been found to induce and bind membrane curvature. This protein’s expression is localized to the brain, most specifically in the frontal cortex. Markedly high expression is observed in fetal cerebellum.

特異性

Human (94% sequence homology).

The antibody recognizes Endophilin-A1.

免疫原

KLH-conjugated linear peptide corresponding to mouse Endophilin-A1.

應用

This Anti-Endophilin-A1 Antibody is validated for use in WB for the detection of Endophilin-A1.

Western Blot Analysis: 1:500 dilution from a previous lot detected Endophilin-A1 in 10 µg of rat brain and mouse brain membrane tissue lysates.

品質

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected Endophilin-A1 in 10 µg of mouse brain tissue lysate.

標靶描述

~ 42 kDa

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable