推薦產品
生物源
rabbit
抗體表格
serum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
rat
包裝
antibody small pack of 25 μL
技術
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同型
IgG
NCBI登錄號
UniProt登錄號
目標翻譯後修改
unmodified
基因資訊
rat ... Gpc1(58920)
一般說明
Glypican-1 (UniProt: P35053; also known as GPC1, HSPG M12) is encoded by the Gpc1 gene (GeneID: 58920) in rat. Glypican-1 is attaches to the plasma membrane via glycosylphosphatidylinositol (GPI) anchors. It is a cell surface proteoglycan that bears heparan sulfate and may act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Glypican-1 is required for proper skeletal muscle differentiation. It sequesters FGF2 in lipid rafts and blocks its binding to FGF receptors. Glypican-1 is specifically enriched on cancer-cell-derived exosomes and levels of glypican-1 positive exosomes correlate with tumor burden and the survival of pre- and post-surgical patients. Glypican-1 expression, both mRNA and protein, is upregulated in human pancreatic cancers cells and adjacent fibroblasts. (Ref.: Melo, SA et al. 2015. Nature. 523(7559):177-82; Kleeff, J et al. 1998. J. Clin. Invest. 102(9), 1662 1673).
特異性
This rabbit polyclonal antibody detects Glypican-1 in Rat C6 glioma cells.
免疫原
Epitope: unknown
GST-tagged recombinant fragment corresponding to the first 423 amino acids of rat Glypican-1.
應用
Anti-Glypican-1 Antibody, Cat. No. ABT1385 is a rabbit polyclonal antibody that detects Glypican-1 and is tested for use in Immunocytochemistry, Immunohistochemistry, and Western Blotting.
Research Category
Cell Structure
Cell Structure
Western Blotting Analysis: A representative lot detected Glypican-1 in rat brain homogenates and rat C6 glioma cells treated with heparitinase (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
Immunocytochemistry Analysis: A representative lot detected Glypican-1 in rat C6 glioma cells (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
Immunohistochemistry Analysis: A representative lot detected Glypican-1 in rat spinal cord and brain (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
Immunocytochemistry Analysis: A representative lot detected Glypican-1 in rat C6 glioma cells (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
Immunohistochemistry Analysis: A representative lot detected Glypican-1 in rat spinal cord and brain (Liang, Y., et. al. (1997). J Cell Biol. 139(4):851-64).
品質
Evaluated by Immunocytochemistry in Rat C6 glioma cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Glypican-1 in Rat C6 glioma cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Glypican-1 in Rat C6 glioma cells.
標靶描述
61.73 kDa calculated.
外觀
Unpurified
Rabbit polyclonal antiserum with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at -20°C from date of receipt.
其他說明
Concentration: Please refer to lot specific datasheet.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類(WGK)
WGK 1
分析證明 (COA)
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