ABS90

Anti-Notch 1 Antibody, extracellular

from rabbit, purified by affinity chromatography

• 同義詞: Notch homolog 1, translocation-associated (Drosophila), Notch (Drosophila) homolog 1 (translocation-associated), Translocation-associated notch protein TAN-1, neurogenic locus notch homolog protein 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human, rat
• 物種活性（以同源性預測）: canine (91% sequence homology), mouse (97% sequence homology), chimpanzee (92% sequence homology)
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI登錄號: NP_001099191
• UniProt登錄號: Q07008
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... NOTCH1(4851) ; rat ... Notch1(25496)

描述

一般說明

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals, which include notch-1. notch-2, notch-3, and notch-4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of notch-1. Mature notch proteins are heterodimeric receptors derived from the cleavage of notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

特異性

This antibody recognizes Notch 1.

免疫原

Epitope: Extracellular domain

GST-tagged recombinant protein corresponding to the extracellular domain of rat Notch 1.

應用

Anti-Notch 1 Antibody, extracellular detects level of Notch 1 & has been published & validated for use in WB, IH(P).

Immunohistochemistry Analysis: 1:400 dilution of this antibody has been shown to detect Notch 1 in gastrointestinal and colorectal carcinoma tissue.

Research Category
Signaling

Research Sub Category
Growth Factors & Receptors

品質

Evaluated by Western Blot in human lymph node lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected Notch 1 on 10 µg of human lymph node lysate.

標靶描述

~260 kDa observed. Notch 1, extracellular is calculated at ~183 kDa

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human lymph node lysate

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable