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Merck
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Key Documents

ABS21

Sigma-Aldrich

Anti-Surfactant Protein B Antibody

from rabbit, purified by affinity chromatography

同義詞:

Pulmonary surfactant-associated protein B, 18 kDa pulmonary-surfactant protein, Pulmonary surfactant-associated proteolipid SPL(Phe), SP-B

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

rat, mouse, human

技術

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... SFTPB(6439)

一般說明

Surfactant Protein B (SP-B) is mostly composed of phospholipids, but also incorporates essential proteins. It is necessary for pulmonary surfactant function and the alveolar type 2 cell phenotype. SP-B deficiency has been known to cause congenital pulmonary alveolar proteinosis. SP-B is thought to protect lungs against endotoxin-induced inflammation. SP-B could be used as a clinical marker in chronic heart failure.

特異性

This antibody recognizes Surfactant Protein B at the Saposin B-type 2 domain.

免疫原

Epitope: Saposin B-type 2 domain
GST-tagged recombinant protein corresponding to human Surfactant Protein B at the Saposin B-type 2 domain.

應用

Immunohistochemistry Analysis: 1:200 dilution from a representative lot detected Surfactant protein B in clara cells in normal rat lung tissue.
Research Category
Signaling
Research Sub Category
Lipid Signaling
This Anti-Surfactant Protein B Antibody is validated for use in WB, IH(P) for the detection of Surfactant Protein B.

品質

Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: 1:5,000 dilution of this antibody detected Surfactant Protein B on 10 µg of human lung tissue lysate.

標靶描述

~16 kDa observed

外觀

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human lung tissue lysate

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Frank Bühling et al.
PloS one, 6(10), e26247-e26247 (2011-10-25)
The 11 human cysteine cathepsins are proteases mainly located in the endolysosomal compartment of all cells and within the exocytosis pathways of some secretory cell types. Cathepsin H (Ctsh) has amino- and endopeptidase activities. In vitro studies have demonstrated Ctsh

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