ABC502

Anti-PAR-4 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: PAR-4, PRKC apoptosis WT1 regulator protein, Prostate apoptosis response 4 protein
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: bovine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), canine (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)
• 技術: western blot: suitable
• NCBI登錄號: NP_002574
• UniProt登錄號: Q96IZ0
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PAWR(5074)

描述

一般說明

PAR-4 is a pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells and sensitizing the cells to diverse apoptotic stimuli causing tumor regression. PAR-4 also seems to be a transcriptional repressor and is involved in regulating APP expression and the cleavage activity of BACE1. PAR-4 interacts with several proteins including WT1, but also various kinases, and structural proteins like Actin, BACE1, SPSB1, SPSB2, and SPSB4. PAR4 is localized in the cytoplasm in non-apoptotic cells but is nuclear localized in cancer and apoptotic cells. PAR-4 is widely expressed and elevated in neurodegenerative diseases such as ALS, Alzheimer, Parkinson and Huntington diseases as well as stroke. PAR-4 is down regulated in cancers.

免疫原

Epitope: C-terminus

GST-tagged recombinant protein corresponding to the C-terminus of human PAR-4.

應用

Anti-PAR-4 Antibody is an antibody against PAR-4 for use in Western Blotting.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Western Blotting in Y-79 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PAR-4 in 10 µg of Y-79 cell lysate.

標靶描述

~45 kDa observed. The calculated molecular weight is 36 kDa, however PAR-4 has been shown as a ~45 kDa band in some western blots (Masters, S.L., et al. (2006). Nature Structural & Mole. Biol. 13(1):77-84).

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable