ABC349

Anti-ABCA7 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: ATP-binding Cassette Sub-family A (ABC1) member 7, ABC1, ABC Transporter 1, ATP-binding Cassette 1, ATP-binding Cassette Transporter 1, CERP, ABCA-SSN, Autoantigen SS-N, Macrophage ABC transporter, ABCA7
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 無性繁殖: polyclonal
• application: ICC; WB
• 物種活性: human
• 技術: immunocytochemistry: suitable; western blot: suitable

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 技術: immunocytochemistry: suitable; western blot: suitable
• UniProt登錄號: Q8IZY2
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... ABCA7(10347)

描述

一般說明

ATP-binding cassette sub-family A member 7 (ABCA7), also known as ABCA-SSN and Macrophage ABC transporter, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. It uses ATP hydrolysis to catalyze the transport of various molecules across cell membranes. ABCA7 is involved in phagocytosis by macrophages of apoptotic cells, binds to APOA1, may function in phospholipid and cholesterol efflux from cells, and may regulate cellular ceramide homeostasis during keratinocyte differentiation The high ABCA7 expression levels in peripheral leukocytes, thymus, spleen and bone marrow indicates a role in the immune system lipid homeostasis. ABCA1 is also highly expressed in fetal tissues, especially the liver.

免疫原

KLH-conjugated linear peptide corresponding to human ABCA7.

應用

Anti-ABCA7 Antibody is a highly specific rabbit polyclonal antibody, that targets ABCA7 & has been tested in western blotting & ICC.

Immunocytochemistry Analysis: 5 µg/mL from a representative lot detected ABCA7 in HEK293 cells.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 1µg/mL of this antibody detected ABCA7 in 15 µg of HEK293 cell lysate.

標靶描述

~234 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~219 kDa and ~234 kDa

外觀

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
HEK293 cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable