ABC338

Anti-IRGM Antibody

from rabbit, purified by affinity chromatography

• 同義詞: IRGM Antibody, Immunity related GTPase family, IFL1, IRGM1, LRG47, LRG-47
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 技術: immunofluorescence: suitable; immunohistochemistry: suitable (paraffin); western blot: suitable
• UniProt登錄號: A1A4Y4
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... IRGM(345611)

描述

一般說明

Immunity-related GTPase family M protein (IRGM), also known as Interferon-inducible protein 1 (IFI1) and LPS-stimulated RAW 264.7 macrophage protein 47 homolog (LRG-47), is a member of the interferon-inducible GTPase family. It induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. IRGM is expressed in colon, small bowel, and peripheral blood leukocytes. Mutations in IRGM have been assoicated with inflammatory bowel disease type 19 which is subdivided into Crohn′s disease and ulcerative colitis phenotypes.

特異性

This antibody recognizes the intermediate domain of IRGM.

免疫原

KLH-conjugated linear peptide corresponding to the intermediate domain of human IRGM.

應用

Detect Immunity-related GTPase family M protein using this rabbit polyclonal antibody, Anti-IRGM Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected IRGM in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IRGM in human brain cells.

品質

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected IRGM in 15 µg of human brain tissue lysate.

標靶描述

~31 kDa observed. Uncharacterized bands may appear in some lysates.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable