推薦產品
生物源
rabbit
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
mouse, rat, human
製造商／商標名
Chemicon®
技術
immunocytochemistry: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
unmodified
基因資訊
human ... HIP1R(9026)
一般說明
Huntingtin-Interacting protein-1 related (HIP1R) is an actin-binding protein that is considered an element of the clathrin-coated pits and vesicles and polymerizes actin. HIP1R is essential for normal actin organization and endocytosis. HIP1R is equipped with a epsin N-terminal homology domain which allows it to bind 3-phosphorylated inositol lipids, which allows HIP1R to function as a tyrosine kinase stabilizing receptor and plays a role in overall cell growth and survival.
特異性
Huntingtin-interacting protein 1 related (HIP1R). By Western blot the antibody recognizes a band at ~116 kDa on P2 microsomal fraction from embryonic rat brain.
免疫原
Synthetic peptide
應用
Detect Huntingtin-Interacting Protein 1 Related (HIP1R) using this Anti-Huntingtin-Interacting Protein 1 Related (HIP1R) Antibody validated for use in WB & IC.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Synapse & Synaptic Biology
Neurodegenerative Diseases
Synapse & Synaptic Biology
Western Blot: a 1:500-1:2,000 dilution of this antibody detected Huntingtin-interacting protein 1 related (HIP1R) in 10 µg of rat brain extract and mouse brain post-nuclear supernatant.A 1:500-1:2,000 dilution of this antibody detected Huntingtin-interacting protein 1 related (HIP1R) in 10 µg of rat brain extract and mouse brain post-nuclear supernatant.
Immunocytochemistry: a previous lot of this antibody was used by an independent laboratory for IC of human cells. (Poupon, V., et al. (2008). PNAS. 105(1): 168-173.)
Optimal working dilutions must be determined by end user.
Immunocytochemistry: a previous lot of this antibody was used by an independent laboratory for IC of human cells. (Poupon, V., et al. (2008). PNAS. 105(1): 168-173.)
Optimal working dilutions must be determined by end user.
標靶描述
~116 kDa
外觀
Format: Purified
Liquid
儲存和穩定性
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Sophia R Majeed et al.
Nature communications, 5, 3891-3891 (2014-05-24)
The clathrin light chain (CLC) subunits participate in several membrane traffic pathways involving both clathrin and actin, through binding the actin-organizing huntingtin-interacting proteins (Hip). However, CLCs are dispensable for clathrin-mediated endocytosis of many cargoes. Here we observe that CLC depletion
Markus Mukenhirn et al.
Cells, 10(2) (2021-03-07)
One of the most fundamental processes of the cell is the uptake of molecules from the surrounding environment. Clathrin-mediated endocytosis (CME) is the best-described uptake pathway and regulates nutrient uptake, protein and lipid turnover at the plasma membrane (PM), cell
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