AB2988

Anti-LYVE1 Antibody

from rabbit, purified by affinity chromatography

• 同義詞: Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, cell surface retention sequence binding protein-1, extracellular link domain containing 1, extracellular link domain-containing 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: mouse (based on 100% sequence homology)
• 技術: immunohistochemistry: suitable
• 同型: IgG
• NCBI登錄號: NP_444477
• UniProt登錄號: Q8BHC0
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... LYVE1(10894)

描述

一般說明

LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 may function in lymphatic hyaluronan transport. Additionally, LYVE1 has a role in tumor metastasis.

特異性

Rat (90% sequence homology).

This antibody recognizes LYVE1.

免疫原

Epitope: Unknown

KLH-conjugated linear peptide corresponding to mouse LYVE1.

應用

Anti-LYVE1 Antibody is an antibody against LYVE1 for use in IH.

Not recommended to work in western blot using mouse liver lysate.

Research Category
Apoptosis & Cancer

Research Sub Category
Tumor Markers

品質

Evaluated by Immunohistochemistry in ovarian cancer tissue.

Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected LYVE1 in ovarian cancer tissue.

標靶描述

~ 40 kDa

聯結

Replaces: 07-538

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Ovarian cancer tissue

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable