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Merck
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重要文件

AB2959

Sigma-Aldrich

Anti-ADAM 9 Antibody, disintegrin domain

from rabbit

同義詞:

ADAM metallopeptidase domain 9 (meltrin gamma), a disintegrin and metalloproteinase domain 9 (meltrin gamma), Cellular disintegrin-related protein, Myeloma cell metalloproteinase, Metalloprotease/disintegrin/cysteine-rich protein 9

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

human

物種活性(以同源性預測)

chimpanzee (based on 100% sequence homology), primate (based on 100% sequence homology)

技術

western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

一般說明

A disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) belongs to a family of transmembrane, membrane-anchored, disintegrin-containing proteins that are involved in several biological functions such as protein ectodomain shedding, cell fusion, and cell adhesion. ADAMs contain several characteristic domains, two of which, the protease and disintegrin domains, are noted for their homology to snake venom metalloprotease. The exact function of ADAM 9 is yet unknown, however it is widely distributed, is found within keratinocytes, and is ideally placed on the cell membrane, which some studies have suggested supports a role in cell migration and motility. Alternative splicing results in two isoforms; isoform 1 is found within the cell membrane and is considered a single-pass type 1 membrane protein, while isoform 2 is secreted. Mutations in ADAM 9 expression are causal to cone-rod dystrophy type 9 or CORD9 which is characterized by visible retinal pigment deposits and loss of cone photoreceptors leading and rod degeneration, ultimately resulting in severe loss of vision.

特異性

Mouse and rat (90% sequence homology).

免疫原

Epitope: disintegrin domain
KLH-conjugated linear peptide corresponding to the disintegrin domain of human ADAM 9.

應用

Detect ADAM 9 using this Anti-ADAM 9 Antibody, disintegrin domain validated for use in WB.
Research Category
Cell Structure
Research Sub Category
MMPs & TIMPs

品質

Evaluated by Western Blot in human chondrocyte cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected ADAM 9 in 10 µg of human chondrocyte cell lysate.

標靶描述

~ 90 kDa observed. 2 isoforms are produced by alternative splicing: Isoform 1 at 91 kDa and Isoform 2 at 72 kDa

聯結

Replaces: AB19025

外觀

Protein A purified
Format: Purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human chondrocyte cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Narkhyun Bae et al.
Acta pharmacologica Sinica, 32(3), 288-294 (2011-03-05)
To examine the role of protein L-isoaspartyl O-methyltransferase (PIMT; EC 2.1.1.77) on the secretion of Aβ peptides. HEK293 APPsw cells were treated with PIMT siRNA or adenosine dialdehyde (AdOX), a broad-spectrum methyltransferase inhibitor. Under the conditions, the level of Aβ

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