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Merck
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重要文件

AB10516

Sigma-Aldrich

抗血管生成素-1抗体

from rabbit

同義詞:

Hepatic fibrinogen/angiopoietin-related protein, PPARG angiopoietin related protein, angiopoietin-like 4, angiopoietin-like 4 protein, angiopoietin-related protein 4, fasting-induced adipose factor, hepatic angiopoietin-related protein, peroxisome prolif

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

100

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

物種活性

horse (95% sequence homology), dog (95% sequence homology), mouse (100% sequence homology), rat (95% sequence homology), bovine (95% sequence homology), mouse, human (90% sequence homology), pig (95% sequence homology)

技術

western blot: suitable

NCBI登錄號

NM_001146.3

UniProt登錄號

O08538

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... ANGPT1(284)

一般說明

哺乳动物原始脉管系统的重塑以形成成熟的心血管系统包括许多指导内皮细胞发育的因素。血管生成素-1是一种与内皮特异性Tie-2受体相互作用的血管生成分泌型蛋白。它主要在发育中的内皮细胞中表达。在胚胎发育过程中，Ang-1结合并诱导Tie-2的酪氨酸磷酸化。Ang-1似乎在介导基质和间充质中起关键作用。它介导血管成熟和稳定。Ang-1可能在心脏发育中起关键作用。Ang-1缺陷小鼠模仿Tie-2缺陷动物表现出的表型。Ang-1的同系物，称为血管生成素-2，可以作为Ang-1和Tie-2的拮抗剂。Ang-1和Ang-2具有约60%的序列同源性。

特異性

该抗体可识别血管生成素-1。

免疫原

该抗体是从用选自小鼠血管生成素-1的KLH偶联合成肽免疫的兔中产生的。

應用

抗血管生成素-1抗体是针对血管生成素-1的抗体，可用于WB。

品質

通过蛋白质印迹在小鼠肾裂解液中进行了评估。
蛋白质印迹分析：： 该批次的1：1,000稀释液在10 µg小鼠肾裂解液中检测到血管生成素-1。

標靶描述

57 kDa

外觀

形式：纯化

分析報告

对照
小鼠肾裂解液

其他說明

浓度：请参考批次特异性浓缩物的检验报告。

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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Yu Zhan et al.
Frontiers in neuroscience, 13, 701-701 (2019-07-30)
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Angara Sureshbabu et al.
Respiratory research, 16, 4-4 (2015-01-17)
Earlier studies have reported that transforming growth factor beta 1(TGFβ1) is a critical mediator of hyperoxia-induced acute lung injury (HALI) in developing lungs, leading to impaired alveolarization and a pulmonary phenotype of bronchopulmonary dysplasia (BPD). However, the mechanisms responsible for
Defang Pang et al.
Experimental & molecular medicine, 50(9), 117-117 (2018-09-07)
We have previously demonstrated that in response to cerebral ischemia (CI), the growth factor angiopoietin-1 (Ang1) and α5β1 integrin are both induced in cerebral vessels, which likely provide positive signals driving the endogenous angiogenic response and vascular protection after CI.
Kunio Kawamura et al.
PloS one, 9(6), e98639-e98639 (2014-06-05)
An angiogenesis factor, angiopoietin-1 (Ang1), is associated with the blood-brain barrier (BBB) disruption after focal cerebral ischemia. However, whether hemorrhagic transformation and cerebral edema after tissue plasminogen activator (tPA) treatment are related to the decrease in Ang1 expression in the

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