8.55029

N-Cyclohexylcarbodiimide,N′-methyl polystyrene

Novabiochem^®

• 分類程式碼代碼: 13111023
• NACRES: NA.22

屬性

• 品質等級: 200
• 產品線: Novabiochem^®
• 形狀: beads
• 反應適用性: reaction type: solution phase peptide synthesis; reactivity: carboxyl reactive
• 製造商／商標名: Novabiochem^®
• 應用: peptide synthesis
• 儲存溫度: 2-8°C

描述

一般說明

N-Cyclohexylcarbodiimide, N-methyl polystyrene ^[1] is an ideal tool for mediating solution phase coupling reactions. Typically, the amine and carboxylic acid are treated with a 2-3 fold excess of resin in DCM or DMF ^[2,3]; a slight excess of carboxyl component over amine component is often used to help drive the reaction to completion. As excess acid and urea by-products remain attached to the resin at the end of the reaction, the product can normally be isolated pure by filtration and evaporation of the reaction mixture. Reactions can be accelerated by the addition of auxiliary nucleophiles such as HOBt; these can be removed using polyamine- or TBD-polystyrene. This resin has also been used in conjunction with DMAP to mediate ester formation ^[4].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] G.M Weinshenker, et al. (1988) Org. Synth., Coll. Vol. VI, 951.
^[2] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
^[3] K. Senton, et al. (2003) J. Comb. Chem., 5, 336.
^[4] M. Cano, et al. (2002) J. Org. Chem., 67, 129.

聯結

Replaces: 01-64-0211

分析報告

Color (visual): slightly beige to brown
Appearance of substance (visual): beads
Loading (determined by HPLC after reaction of Z-Phe-OH with cyclohexylamine): ≥ 1.3 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-2 % DVB), 200 - 400 mesh.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable