8.52378

Fmoc-Phe(SO3Na)-OH

Novabiochem^®

• 同義詞: Fmoc-Phe(SO3Na)-OH, N-α-Fmoc-4-sulfophenylalanine sodium salt
• 經驗公式（希爾表示法）: C₂₄H₂₀NNaO₇S
• 分子量：: 489.47
• 分類程式碼代碼: 12352209

屬性

• 品質等級: 200
• 產品線: Novabiochem^®
• 形狀: powder
• 反應適用性: reaction type: Fmoc solid-phase peptide synthesis
• 製造商／商標名: Novabiochem^®
• 應用: peptide synthesis
• 官能基: sulfonic acid
• 儲存溫度: 15-25°C

描述

一般說明

Introduction of 4-sulfo-phenylalanine is an effective strategy for increasing solubility of a peptide. This amino acid has also been employed in analogs of angiotensin 2 ^[1], phytosulfokine ^[2], and cyclolinopeptide A ^[3]. Its incorporation during solid phase synthesis using Fmoc-Phe(SO3Na)-OH is best carried out with base-mediated coupling methods such as PyBOP^® or HBTU.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] E. Escher, et al. (1983) , 66, 1355.
^[2] A. Bahyrycz, et al. (2004) , 10, 462.
^[3] Y. Fujiwara, et al. (1994) , 42, 724.

分析報告

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in DMF): -17.0 - -15.0 °
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Purity TLC (BAW 1): ≥ 97.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable