8.52095

Fmoc-Lys(Mca)-OH

≥97.0% (HPLC), for peptide synthesis, Novabiochem^®

• 同義詞: Fmoc-Lys(Mca)-OH, N-α-Fmoc-N-ε-7-methoxycoumarin-4-acetyl-L-lysine
• 經驗公式（希爾表示法）: C₃₃H₃₂N₂O₈
• CAS號碼: 386213-32-7
• 分子量：: 584.62
• MDL號碼: MFCD03791024
• 分類程式碼代碼: 12352209
• NACRES: NA.22

屬性

• 產品名稱: Fmoc-Lys(Mca)-OH, Novabiochem^®
• 品質等級: 200
• 產品線: Novabiochem^®
• 化驗: ≥97% (TLC); ≥97.0% (HPLC)
• 形狀: powder
• 反應適用性: reaction type: Fmoc solid-phase peptide synthesis
• 製造商／商標名: Novabiochem^®
• 應用: peptide synthesis
• 官能基: amine
• 儲存溫度: −20°C
• SMILES 字串: N([C@@H](CCCCNC(=O)Cc4c5c([o][c](c4)=O)cc(cc5)OC)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C33H32N2O8/c1-41-21-13-14-22-20(17-31(37)43-29(22)18-21)16-30(36)34-15-7-6-12-28(32(38)39)35-33(40)42-19-27-25-10-4-2-8-23(25)24-9-3-5-11-26(24)27/h2-5,8-11,13-14,17-18,27-28H,6-7,12,15-16,19H2,1H3,(H,34,36)(H,35,40)(H,38,39)/t28-/m0/s1
• InChI 密鑰: BWJJONDPLYEAMC-NDEPHWFRSA-N

描述

一般說明

A modified lysine derivative for the preparation of fluorogenically-labeled peptides by Fmoc SPPS ^[1]. The Mca group fluoresces at 405 nm when stimulated at 340 nm, and is most commonly used in conjunction with Dabcyl and 2,4-dinitrophenyl quenching groups. Recently, Fmoc-Lys(Mca)-OH has been used to prepare lanthanide-based luminescent proteins by native chemical ligation ^[2]. Lys(Mca) was found to be stable to HF cleavage conditions used to synthesize the thioester fragments needed for ligation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Chromogenic Labeling of Synthetic Peptides

Literature references

^[1] J. L. Lauer-Fields, et al. (2001) Biochemistry, 40, 5795.
^[2] C. F. W. Becker, et al. (2004) Bioconjugate Chem., 15, 1118.

聯結

Replaces: 04-12-1233

分析報告

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Water (K. F.): ≤ 2.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable