616394

TPEN

• 同義詞: TPEN
• 經驗公式（希爾表示法）: C₂₆H₂₈N₆
• CAS號碼: 16858-02-9
• 分子量：: 424.54
• MDL號碼: MFCD00036918
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥97% (titration)
• 品質等級: 100
• 形狀: solid
• 反應適用性: reagent type: chelator
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: tan
• 溶解度: ethanol: 10 mg/mL; 0.1 M phosphate pH 7.0: 25 μM; DMSO: soluble
• 運輸包裝: ambient
• 儲存溫度: 15-25°C
• InChI: 1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
• InChI 密鑰: CVRXLMUYFMERMJ-UHFFFAOYSA-N

描述

一般說明

脂溶性重金属螯合剂，可穿过人工膜和天然膜。某些技术中用于测量细胞内游离Ca²⁺水平的辅助试剂。也可用于从阿尔茨海默’病脑组织中提取Aβ淀粉样沉积物。对重金属有极高的亲和力，但对Ca²⁺和Mg²⁺的亲和力较低。与Zn²⁺螯合时诱导DNA断裂，并诱导胸腺细胞凋亡。从脂质体捕获的QUIN 2（目录号551826）中去除重金属。

脂溶性重金属螯合剂，可穿过人工膜和天然膜。某些技术中用于测量细胞内游离Ca²⁺的辅助试剂。对重金属有极高的亲和力，但对Ca²⁺和Mg²⁺的亲和力较低。与Zn²⁺螯合时诱导DNA断裂，并导致胸腺细胞凋亡。从脂质体捕获的QUIN 2中去除重金属。显示在从阿尔茨海默′病脑组织中提取Aβ沉积物是有用的。

應用

• Poly(ADP-ribosyl)ation of p53 contributes to TPEN-induced neuronal apoptosis.: This study investigates the role of poly(ADP-ribosyl)ation of the tumor suppressor protein p53 in neuronal apoptosis induced by TPEN, highlighting mechanisms of cell death in neurodegenerative diseases (Kim HL et al., 2015).


• Essential role of p53 in TPEN-induced neuronal apoptosis.: This article explores the critical involvement of the p53 protein in apoptosis initiated by TPEN in neuronal cells, offering insights into potential therapeutic targets for neuroprotection (Ra H et al., 2009).


• Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore.: Demonstrates how Clioquinol, similar to TPEN, functions as a zinc ionophore to induce autophagy, particularly in neurological contexts, which may be relevant for understanding TPEN′s mechanisms (Park MH et al., 2011).

警告

毒性：标准处理（A）

重構

复溶后，等分并在惰性气体下冷冻（-20°C）。或者，用盐酸酸化（pH ≤3），以便长期贮藏。贮备溶液在-20°C下可稳定保存至多3个月。

其他說明

Fonte, J., et al. 2001.J. Alzheimer’s Dis. 3, 209.
Cherny, R.A., et al. 1999.J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995.Biochem.J.312, 919.
Jiang, S., et al. 1995.Lab. Invest.73, 111.
Sheridan, R.E. and Deshpande, S.S.1995.Toxicon33, 539.
McCabe, M.J., et al. 1993.Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992.J. Biol. Chem.267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp.Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989.J. Cellular Physiol.138, 593.
Raspe, E., et al. 1989.Eur. J. Pharmacol.163, 345.
Arslan, L.P., et al. 1985.J. Biol. Chem.260, 2719.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable