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Key Documents

577801

Sigma-Aldrich

Tau小鼠单克隆抗体(TAU-5)

liquid, clone TAU-5, Calbiochem®

同義詞:

Anti-Tau antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.43

生物源

mouse

品質等級

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

TAU-5, monoclonal

形狀

liquid

不包含

preservative

物種活性

mouse, human, sheep, rat

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
avoid repeated freeze/thaw cycles

同型

IgG1

運輸包裝

wet ice

儲存溫度

−70°C

目標翻譯後修改

unmodified

基因資訊

human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)

一般說明

蛋白G纯化的小鼠单克隆抗体。识别约45-68 kDa磷酸化和非磷酸化形式的tau。
识别~45-68 kDa Tau蛋白。
该小鼠抗Tau mAb(TAU-5)经过验证,可用于冷冻切片、免疫印迹、免疫沉淀、石蜡切片以检测Tau。

免疫原

纯化的牛微管相关蛋白
表位:中心区域内

應用

冷冻切片(1-2 µg/ml)

免疫印迹(1 µg/ml)

免疫沉淀(每200-500 µg细胞裂解液 10 µg)

石蜡切片(1-2 µg/ml,需要热预处理)

包裝

特定浓度批号请参考小瓶的标签。

警告

毒性:标准处理(A)

外觀

在PBS中。

重構

初次解冻后,分装冻存(-70°C)。如果浓度为<50 µg/ml,请勿贮藏没有载体蛋白的稀释抗体。

其他說明

Papasozomenos, S.C. and Shanavas, A., 2002.Proc.Natl.Acad.Sci. USA99, 1140.
Rapoport, M., eta al.2002.Proc.Natl.Acad.Sci. USA99, 6364.
当用于福尔马林/石蜡包埋切片时,在10 mM枸橼酸盐缓冲液(pH 6.0)中煮沸组织切片10-20分钟,然后在抗体培养前在室温下冷却20分钟,从而增强染色。Tau mRNA的交替剪接和差异磷酸化促成tau的异质性。不与微管蛋白的其他MAPS发生交叉反应。识别天然和磷酸化形式的tau。合适的工作稀释度由与测定条件相关的变量决定。

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Shuo Pang et al.
Frontiers in molecular neuroscience, 15, 1025066-1025066 (2023-01-27)
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive neurodegeneration and cognitive decline. Evodiamine, a main component in Chinese medicine, was found to improve cognitive impairment in AD model mice based on several intensive studies. However, evodiamine has high
Zhuohui Luo et al.
Drug design, development and therapy, 16, 3285-3296 (2022-10-04)
Alzheimer's disease (AD) is the most common neurodegenerative disease whose patients suffered from cognitive impairments. In our study, a novel 1,2,4-Oxadiazole derivative wyc-7-20 was synthesized, which showed low cytotoxicity and potent neuroprotective effect at the cellular level. Improved cognitive impairments
Michela Guglielmotto et al.
Journal of Alzheimer's disease : JAD, 77(3), 1339-1351 (2020-08-18)
The risk of developing Alzheimer's disease as well as its progression and severity are known to be different in men and women, and cognitive decline is greater in women than in men at the same stage of disease and could
Weijiang Dong et al.
Journal of neuroscience research, 87(14), 3176-3185 (2009-05-28)
Tau function is regulated by phosphorylation, and abnormal tau phosphorylation in neurons is one of the key processes associated with development of Alzheimer's disease and other tauopathies. In this study we provide evidence that phospholipid transfer protein (PLTP), one of
Ram Fridlich et al.
Molecular & cellular proteomics : MCP, 8(6), 1206-1218 (2009-03-13)
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