566322-M

SIRT1 Inhibitor III

The SIRT1 Inhibitor III, also referenced under CAS 49843-98-3, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 同義詞: SIRT1 Inhibitor III, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527
• 經驗公式（希爾表示法）: C₁₃H₁₃ClN₂O
• CAS號碼: 49843-98-3
• 分子量：: 248.71
• MDL號碼: MFCD03009471
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• 儲存溫度: 2-8°C
• InChI: 1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
• InChI 密鑰: FUZYTVDVLBBXDL-UHFFFAOYSA-N

描述

一般說明

A cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC₅₀ = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC₅₀ = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.

生化／生理作用

Primary Target
SIRT1

Target IC₅₀: 98 nM against SIRT1

警告

Toxicity: Irritant (B)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Solomon, J.M., et al. 2006. Mol. Cell. Biol.26, 28.
Napper, A.D., et al. 2005. J. Med. Chem.48, 8045.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3