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5.08409

Sigma-Aldrich

巴弗洛霉素A1

≥90% (HPLC), liquid,V-ATPase inhibitor, Calbiochem

同義詞:

InSolution 巴弗洛霉素 A1, InSolution 巴弗洛霉素 A1,≥97% HPLC测定

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About This Item

經驗公式(希爾表示法):
C35H58O9
CAS號碼:
分子量::
622.83
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

巴弗洛霉素A1, InSolution, ≥90%, A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase

品質等級

化驗

≥90% (HPLC)

形狀

liquid

儲存期限

2 yr

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

儲存溫度

−20°C

InChI

1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI 密鑰

XDHNQDDQEHDUTM-JQWOJBOSSA-N

一般說明

一种大环内酯类抗生素,可作为液泡型H+-ATP酶(V型;Ki=0.5 nM)的特异性抑制剂,是区分不同类型ATP酶的有价值的工具。据报告,可选择性地抑制β-分泌酶,这是一种参与淀粉样蛋白前体蛋白(APP)加工的酶。阻断巨噬细胞中的溶酶体胆固醇运输。已知会干扰脑细胞中的pH值调节。抑制体内体外的骨吸收。在细胞活率测定中,已对多种细胞系具有细胞毒性作用。

生化/生理作用

主要靶标
液泡型H+-ATP酶
细胞可渗透性:具有

包裝

用惰性气体包装

警告

毒性:标准处理(A)

重構

初次融化后,等分并冷冻(-20°C)。等分试样在-20°C下可稳定保存1年。仅使用新鲜的DMSO进行进一步稀释。

其他說明

Sinha, S., and Lieberburg, I. 1999.Proc.Natl.Acad.Sci. USA96, 11049.
Calvert, C.M., and Sanders, D. 1995.J. Biol. Chem.270, 7272.
Nishihara, T., et al. 1995.Biochem.Biophys.Res. Commun.269, 255.
Crider, B.P., et al. 1994.J. Biol. Chem.269, 17379.
Palokangas, H., et al. 1994.J. Biol. Chem.269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994.J. Bone Miner.Res.9, 1575.
Drose, S., et al. 1993.Biochemistry32, 3902.
Furuchi, T., et al. 1993.J. Biol. Chem.268, 27345.
Bowman, E.J., et al. 1988.Proc.Natl.Acad.Sci. USA85, 7972.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

188.6 °F - (refers to pure substance)

閃點(°C)

87 °C - (refers to pure substance)


分析證明 (COA)

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