5.05758

氧化型ATP（oATP）

• 同義詞: 氧化型ATP（oATP）
• 經驗公式（希爾表示法）: C₁₀H₁₄N₅O₁₃P₃
• CAS號碼: 71997-40-5
• 分子量：: 505.17
• MDL號碼: MFCD00056956
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥97% (HPLC)
• 品質等級: 100
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: water: 50 mg/mL
• 儲存溫度: −20°C
• InChI: 1S/C10H14N5O13P3.Na/c11-9-8-10(13-4-12-9)15(5-14-8)7(2-17)26-6(1-16)3-25-30(21,22)28-31(23,24)27-29(18,19)20;/h1-2,4-7H,3H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);
• InChI 密鑰: KOCWSVPHHGJWHA-UHFFFAOYSA-N

描述

一般說明

Oxidized ATP (oATP) is a Schiff-base-forming reagent is utilized as an antagonist at the P2X7 receptor for several years. It was initially identified as an affinity reagent for nucleotide-binding proteins. oATP reduces nuclear factor kappa B (NF-κB) activation and IL-8 release in cells lacking P2X7R, suggesting that some anti-inflammatory effects of oATP may not be solely attributed to the blockade of the P2X7R. This effect of oATP is reminiscent of the action of other natural or synthetic Schiff-base-forming reagents with immunomodulatory activity.

應用

Oxidized ATP (oATP) may be used to study its effects on the proinflammatory responses in human umbilical vein endothelial cells (HUVEC), HEK293 cells, and 1321N1 astrocytes that lack expression of P2X7R.

生化／生理作用

可逆：否

警告

毒性：标准处理（A）

其他說明

Vergani, A., et al. 2013.Diabetes62, 1665.
DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378.
Wiley, J.S., et al. 1994.Br. J. Pharmacol.112, 946.

Murgia, M., et al. 1992.J. Biol. Chem.268, 8199.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable