5.05226

Pancuronium Dibromide

• 同義詞: Pancuronium Dibromide, 1,1ʹ-(3α,17β-Dihydroxy-2α,5β-androstan-2-β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide
• 經驗公式（希爾表示法）: C₃₅H₆₀N₂O₄ · Br₂
• CAS號碼: 15500-66-0
• 分子量：: 732.67
• MDL號碼: MFCD00079223
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥98% (NMR)
• 品質等級: 100
• 形狀: solid
• 效力: 5.5 nM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: water: 100 mM
• 儲存溫度: 2-8°C
• SMILES 字串: [Br-].[Br-].[N+]6(CCCCC6)([C@@H]1[C@@H]([C@@]2([C@H]([C@H]3[C@@H]([C@@]4([C@H](C[C@@H]([C@H](C4)[N+]5(CCCCC5)C)OC(=O)C)CC3)C)CC2)C1)C)OC(=O)C)C
• InChI: 1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
• InChI 密鑰: NPIJXCQZLFKBMV-YTGGZNJNSA-L

描述

一般說明

A highly potent competitive antagonist selective for nAChRs (IC₅₀ = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.

生化／生理作用

Primary Target
nAChR

警告

Toxicity: Toxic (F)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Lowenick et al., 2001. Eur. J. Pharmacol.413, 31.

Melnikov, L., et al., 1999. Gen Pharmacol.33, 313.

Maestrone, E., et al., 1994. Br. J. Pharmacol.111, 283.

Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol.335, 367.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable