5.00500

MALT1 Inhibitor II, Mepazine Hydrochloride

• 同義詞: MALT1 Inhibitor II, Mepazine Hydrochloride, 10-((1-Methylpiperidin-3-yl)methyl)-10H-phenothiazine, Hydrochloride, 10-((1-Methyl-3-piperidyl)methyl)phenothiazine, Hydrochloride, 10-((1-Methyl-3-piperidinyl)methyl)-10H-phenothiazine, Hydrochloride, MALT-1 Inhibitor II, Mucosa-Associated Lymphoid tis
• 經驗公式（希爾表示法）: C₁₉H₂₃ClN₂S
• CAS號碼: 2975-36-2
• 分子量：: 346.92
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥97% (HPLC)
• 品質等級: 100
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: gray to off-white
• 溶解度: H₂O: 2.5 mg/mL; DMSO: 25 mg/mL
• 儲存溫度: −20°C
• InChI: 1S/C19H22N2S.Cl/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21;/h2-5,8-11,15H,6-7,12-14H2,1H3;
• InChI 密鑰: ZGQUIYCUOPQIDJ-UHFFFAOYSA-N

描述

一般說明

Mepazine hydrochloride is a cell-permeable phenothiazine derivative that inhibits mucosa-associated lymphoid tis 1(MALT1). It does not inhibit the caspase 3 or 8 proteolytic activity in a reversible and non-competitive manner. It blocks anti-CD3/CD28-stimulated IL-6 production in primary murine CD4⁺ T-cell and human peripheral blood mononuclear cell (PBMC) cultures. Mepazine has been observed to inhibit the MALT1 activity in activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL)and RelB cleavage, resulting in effective blockage of nuclear factor (NF-κB)-dependent interleukin-6, 10 as well as anti-apoptoticB-cell lymphoma - extra-large (Bcl-xL) and FLIP-L expression. Mepazineshows ABC-DLBCL-selective cytotoxicity over GCB-DLBCL both in cultures in vitro and in mice in vivo.

生化／生理作用

Cell permeable: yes

Primary Target
MALT1

警告

Toxicity: Standard Handling (A)

外觀

Supplied as a hydrochloride salt.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

The molecular weight for this compound isbatch-specific due to variable water content. Please refer to the vial label orthe certificate of analysis for the batch-specific molecular weight. Themolecular weight provided represents the baseline molecular weight withoutwater.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable